ROS and Male fertility ...5

ROS and Male fertility ...5








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ROS and Male fertility ...5
Posted in 2013

At low concentrations, ROS are metabolic intermediates in the metabolism of prostanoids, in gene regulation and cellular growth and in signal transduction . At high concentrations, ROS exert bionegative effects and damage all major classes of biomolecules.
During reproduction, ROS are involved in many important mechanisms of sperm physiology. An increase in ROS generation at the beginning of capacitation is followed by an increase in tyrosine phosphorylation . The motility was associated with the generation of superoxide anion and a phosphorylation of tyrosine residues.
Furthermore, the acrosome reaction was associated with an extracellular superoxide anion of spermatozoa . In the male genital tract, ROS are generated by spermatozoa and leukocytes including neutrophils and macrophages. In the semen, sperm cells are one of the major cellular sources of ROS. The male germ cells produced a small amount of ROS from the earliest stages of the development . They are involved in the sperm chromatin condensation, regulating the number of germ cells by induction of apoptosis or proliferation of spermatogonia . In the mature sperm, ROS play an important role in the capacitation, acrosome reaction and sperm motility, and they can also function as signaling molecules. There are at least two mechanisms of their production: the membrane nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, an enzyme complex that is contained in the cell membrane, and the mitochondria.

My advise
1...  Oxygen is important for our life.   Without oxygen we cannot survive
2...  Oxygen is important for digesting our food
3...  Oxygen is important for our brain, lungs and kidney function,, cleaning our blood etc..
4...  Oxygen is important for sperm health of the male
5...  Follow healthy food for your body and sperm health

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