Sperm disorders - Hormonal and Immune system

Sperm disorders - Hormonal and Immune system


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Sperm disorders - Hormonal and Immune system
Posted in 2015

Failure of the pituitary to release luteinizing hormone (LH) and follicle stimulating hormone (FSH) causes failure of the testis to produce testosterone and sperm. This condition is diagnosed by low testosterone accompanied by relatively low LH levels. The most extreme example of pituitary failure is Kallmann syndrome, which may be treated with human chorionic gonadotropin (hCG) and recombinant FSH, often requiring treatment periods of a year or more. Milder forms of pituitary problems are common and may be treated with clomiphene citrate if the pituitary is responsive.
Failure of the Leydig cells in the testis to make testosterone results in low levels of testosterone accompanied by very high levels of LH as the negative feedback of testosterone on the pituitary is decreased. Treatment is surgical extraction of sperm if possible, as the body is already providing its own hormonal stimulation.
Testosterone therapy is not used as a treatment for male fertility.
High levels of the hormone estradiol may impair male fertility; this condition can be treated with medications such as anastrozole (Arimidex). High levels of sex hormone binding globulin may also lower the amount of effective testosterone, referred to as “bioavailable” testosterone. If the total or bioavailable testosterone is too low, clomiphene citrate may be used to increase the production of testosterone in the testes.
White blood cells in the semen release toxic chemicals that may affect sperm function. Antioxidants, antibiotics and anti-inflammatory medication may help prevent sperm damage by excessive white blood cells in the semen.
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